【摘要】 目的　探讨乙醇性肝损害的发病机制 ,并研究维生素E对乙醇性肝损害的保护作用。方法　昆明种小鼠 30只 ,分为三组 :正常对照组 (自由饮水 ,不做其他处理 )、乙醇组 (自由饮用 2 5 %乙醇 8周 )、乙醇 +维生素E组 (自由饮用 2 5 %乙醇 8周 ,同时经口给予维生素E2 0 0mg/kg ,每天一次 ,共 8周 )。分别测定血清丙氨酸转氨酶、肝匀浆蛋白含量、肝匀浆丙二酰乙醛含量及肝匀浆超氧化物歧化酶、过氧化氢酶、谷胱甘肽、谷胱甘肽 S 转移酶、谷胱甘肽还原酶、谷胱甘肽过氧化酶的活性。结果　摄入乙醇 8周后多种抗氧化酶及抗氧化物质发生改变 ,维生素E可拮抗乙醇的上述作用 ,使指标的改变发生逆转。结论　维生素E对慢性乙醇性肝损害有保护作用更多还原

【Abstract】 Aim To study the mechanism of ethanol hepatic injury and on which the protective effects of vitamin E in mice.Methods 30 mice were divided into three groups:A:control group (drinking water freely);B:ethanol group (drinking 2.5% ethanol freely,8 wk);C:ethanol+vitamin E group (drinking 2.5% ethanol freely,taking vitamin E 200 mg/kg,orally,qd for 8 wk).Detecting the serum alanine transaminase (sALT),liver tissue MDA,catalase(Cat),superoxide dismutase(SOD),GSH,glutathione s-transferase glutathione reductase(GSH-Re) and glutathione peroxidase(GSH-Px).Results sALT,MDA,SOD,GSH-Re,GSH-Px et al were changed significantly( P <0.05).vitamin E could reverse thier changes,there was significantly difference between group C and B.Conclusions Vitamin E could protect the mice liver from ethanol injury.更多还原