【摘要】 目的　探讨阳性、阴性症状精神分裂症患者和正常对照组三者间血清总睾丸酮 (T -Tes)和游离睾丸酮 (F -Tes)水平的变化。方法　采用放射免疫分析法 (RIA)和酶联免疫分析法 (ELISA) ,对阳性症状患者 (78例 )、阴性症状患者 (94例 )和正常人对照组 (10 0例 )的血清T -Tes和F -Tes水平进行测量和比较。结果　阴性症状患者组血清T -Tes和F -Tes水平明显低于阳性症状患者组和正常对照组 ,差异有显著性 (P <0 .0 5 ,P <0 .0 5 ) ;阳性症状患者组血清T -Tes和F -Tes水平与正常对照组相比较 ,虽有差异但无显著性 (P >0 .0 5 )。结论　精神分裂症患者的血清Tes水平存在着一定的改变 ,尤以阴性症状患者血清Tes水平处于低值状态 ,提示该型患者下丘脑 -垂体 -性腺轴系统功能低下。更多还原

【Abstract】 Objective To observe the change of serum total testosterone level(T-Tes) and serum free testosteronel level(F-Tes) in schizophrenic patients with negative and positive symptoms and also in normal control.Method Chose male patients with first onset whose diagnosis met the criteria of CCMD-2-R.The types of symptom were defined by positive and negative symptom scale(PANSS).Radioimmunoassay(RIA) and enzyme linked immunoassay(ELISA) were used to test and study serum T-Tes and F-Tes level of 78 cases of schizophrenic patients with positive symptoms,94 cases with negative symptoms and 100 cases of normal control.Results Serum T-Tes and F-Tes level of schizophrenic patients with negative symptoms is significantly lower than that of patients with positive symptoms and of normal control,the difference is distinct( P<0.05,P<0.05 ).Serum T-Tes and F-Tes level of schizophrenic patients with positive symptoms and of normal control is not significantly different( P >0.05).Conclusions Serum Tes of schizophrenic patients has certain change,especially the low serum Tes level of schziophrenic patients with negative symptoms shows the hypofunction of hypothalamua hypophysis sex gland axis of those patients.更多还原