节点文献
侧链含有鬼臼毒素高分子抗癌药物的合成
SYNTHESIS OF THE POLYMERIC ANTICANCER DRUGS COVALENTLY LINKED PODOPHYLLOTOXIN
【摘要】 分别用可溶性淀粉、羧甲基纤维素钠和甲壳胺为载体与鬼臼毒素合成了三种侧链含有鬼臼毒素高分子抗癌药物。在pH 7.4的缓冲溶液中对鬼臼毒基羰甲基淀粉 ,鬼臼毒基羰甲基纤维素和鬼臼毒基羰甲基甲壳胺的体外水解释放进行了考查
【Abstract】 Three series of macromolecular drugs covalently linked podophyllotoxin are synthesized by the use of soluble starch,carboxylmethylcellulose and chitosan as carries.The hydrolysis delivery of podophyllotoxin from soluble starch,CMC Na and chitosan in buffer(pH 7.4)was researched.
【关键词】 鬼臼毒素;
高分子载体药物;
可溶性淀粉;
羧甲基纤维素钠;
甲壳胺;
【Key words】 Podophyllotoxin; Polymeric drug; Soluble starch; Carboxylmethylcellulose; Chitosan;
【Key words】 Podophyllotoxin; Polymeric drug; Soluble starch; Carboxylmethylcellulose; Chitosan;
- 【文献出处】 天然产物研究与开发 ,Natural Product Research and Development , 编辑部邮箱 ,2001年05期
- 【分类号】TQ464
- 【被引频次】12
- 【下载频次】229