【摘要】 目的 :明确中药脂肝清对高脂血症防治作用 ,探讨其作用机制。方法 :以饲喂高脂饲料复制高胆固醇血症家兔模型 ,观察血清和肝脂质代谢 ,并且采用脂肝清进行预防实验 ,同时与一类降脂药洛伐他汀 (Lovastatine)作对照。结果 :1)中药明显降低血清TC、LDL C、TC/HDL C比值 (P<0 01或P<0 05) ,降低血清氨基转移酶活力 (P<0 01)。2)中药明显降低肝TC、TG及LDL C含量。结论 :脂肝清具有调整血清脂质代谢 ,促进肝组织中脂质的排泄及保护肝功能等作用。更多还原

【Abstract】 Objective:ToobservetheZhiGanQingChi nesedrugsin preventing andtreatmentofhypercholes terolaemia.Method:Thisexperimentestablishedhyperc holesterolaemiamodelofrabbitbyfeedingheavydosageof cholesterolandobservedthechangesoflipoprotein metabolismofinbloodandliver,itfoundouttheeffectof ZhiGanQingChinesedrugsinpreventingofhypercholes terolaemiacomparingwiththeLovastatine.Result:(1)The Chinesedrugsmarkedlyloweredtotalcholesterol(TC), low -densitylipoproteincholesterol(LDL -C),TC/ HDL -Crate(P<0.01orP<0.05),andmarkedlylow eredactivityoftrans -aminaseinserum(P<0.01).(2) TheChinesedrugsmarkedlyloweredTC,triglicerid(TG), LDL -Cinliver.Conclusion:TheChinesedrugslowered lipidinserum,promotedmetabolismoflipidinliverand protectedthefunctionofliver.更多还原