【摘要】 28 0只大鼠随机分组 ,分别静脉滴注不同剂量的果糖 1,6二磷酸镁 (FDP- Mg) ,在给定时间点采血 ,酶法测定 FDP血药浓度 ,原子吸收分光光度法测定 Mg2 +血药浓度 ,旨在研究 FDP- Mg在大鼠体内的主要动力学特征。结果发现 :大鼠尾静脉滴注 FDP- Mg三种剂量后 ,Mg2 +的血药浓度 -时间曲线符合二室开放模型 ,其 T1 / 2α为 12 .0～ 16 .9m in,T1 / 2β为 10 3.5 9～ 118.46 m in,分布容积 Vd为 1.6 1～ 1.78L/ kg,各剂量组间主要动力学参数 CL、T1 / 2 el、Vss、AUC/X0 经 t检验差异无显著性 (P>0 .0 5 ) ,显示非剂量依赖性特征。FDP的血浆消除半衰期 T1 / 2 el为 8～ 10 m in,MRT为 19～ 2 2 min,CL为 (0 .0 11～ 0 .0 31) L· kg- 1 · min- 1 。在 12 5～ 5 0 0 mg/ kg范围内 ,FDP呈线性消除 ,各剂量间主要动力学参数统计学差异无显著性。 FDP和 Mg2 +的药代动力学特征差异较大 ,提示 FDP- Mg经静脉注射进入生物体后 ,可解离为 FDP、 Mg2 +两部分 ,二者分别按照各自的药代动力学特征从体内消除。更多还原

【Abstract】 Wistar rats were divided into 3 groups. A single dose of 125, 250, 500 mg/kg of fructose 1,6 diphosphage (FDP) Mg were given by intravenous drop. Serial blood samples were collected at designed time points. The plasma FDP concentration was measured by using enzymology method and the plasma Mg 2+ concentration was detected by atomic absorption spectrophotometry (AAS). After intravenous drop of single dose, the plasma concentration versus time curves of Mg 2+ conformed to two compartment model. T 1/2α was 12.01～16.9 min, T 1/2β was 103.59～118.46 min and Vd was 1.61～1.78 L/kg. The main parameters, including CL, T 1/2el , V ss , and AUC/X 0 , appeared to be dose independent. The characters of the C T curves of FDP were different from that of Mg 2+ . Non compartment model was used to calculate the main pharmacokinetic parameters of FDP. T 1/2el was 8～10 min. MRT was 19～22 min and CL was 0.011～0.031 L·kg -1 ·min -1 . FDP was eliminated linearly. AUC and C max were increased in a dose proportional manner. The difference of the parameters between FDP and Mg 2+ suggested that FDP Mg could be divided into two parts, FDP and Mg 2+ , and then, they could be eliminated from the organism according to their own routes respectively.更多还原