【摘要】 观察在体外循环中应用大剂量抑肽酶对术后出血的影响。2 0例成人体外循环心脏直视手术患者 ,随机分为 2组 :抑肽酶组和对照组。结果显示 ,抑肽酶组术后 6h和 2 4 h引流量较对照组显著降低 ( P<0 .0 5 )。认为在体外循环中大剂量抑肽酶应用通过对血小板功能的保护和抗纤溶作用从而大大减少了术后患者渗血量更多还原

【Abstract】 The effect of high-dose aprotinin during cardiopulmonary bypass (CPB) on decrease of hemorrhage after operation was investigated. Twenty adult patients who underwent CPB in cardiac surgery were randomly divided into two groups (n=10 in each): Aprotinin group and control group. The results showed that hemorrhagic volume in the Aprotinin group 6 h and 24 h after operation was significantly decreased as compared with that in the control group (P<0 05. It was suggested that administration of high-dose aprotinin in CPB could significantly decrease the hemorrhagic volume after operation through protecting thrombocytic function and anti-fibrinogenolysis.更多还原