【摘要】 为探讨脱氧核糖核酸 ( DNA) /角蛋白 ( cytokeratin,CK)双参数流式细胞术 ( flow cytom etry,FCM)检测肺癌的价值。对 5 8例癌症患者和 2 2例胸部良性疾病患者的肺泡灌洗液细胞进行 DNA/CK双参数 ,DNA单参数及细胞病理学检查。结果以非整倍体阳性为标准 ,诊断肺癌的阳性率 DNA/CK双参数 ,DNA单参数分别为 91.4 % ,75 .9% ;而细胞病理学的阳性率则为 70 %。DNA/CK双参数检测法与另两种检测法之间有显著性差异 ( P<0 .0 5 )。提示肺泡灌洗液细胞 DNA/CK双参数法是诊断肺癌的更为敏感的检查方法。更多还原

【Abstract】 To investigate the diagnostic value of DNA/cytokeratin (CK) biparametric method in lung cancer, the DNA/CK biparameters, DNA single parameter of alveolar lavage fluid cells in 58 cases of lung cancer and 22 cases of benign diseases of lung were measured and pathological examination performed Aneuploidy was used as a diagnostic criterion The positive rate of DNA/CK biparameters and DNA single parameter for lung cancer was 91 4 % and 75 9 % respectively The positive rate of cellular pathology of lavage fluids was 70 % There was a significant difference in the positive rate for lung cancer between the DNA/CK method and the other two methods ( P <0 05) It was suggested that DNA/CK biparameteric method of alveolar lavage fluids might be a more sensitive method in the diagnosis of lung cancer更多还原