【摘要】 目的 :观察奈西雅预防恶性血液病患者联合化疗所致胃肠反应的疗效和安全性 ,并探讨影响其疗效的因素。方法 :随机选取 38例恶性血液病患者 ,于化疗前 15分钟静脉推注奈西雅 0 .3mg或 5 μg/ kg,每日 1次。结果 :奈西雅对食欲、恶心、呕吐改善的有效率分别为 84.2 %～ 92 .0 %、71.0 %～ 92 .0 %、90 .3%～ 10 0 %。不良反应轻 ,主要为便秘 (3例 )、头晕 (1例 )。双药联合组化疗第 2日对食欲缺乏的有效率 (10 0 % ) ,第 1日 12～ 18小时对恶心的有效率(10 0 % )及呕吐的完全控制率 (10 0 % )明显优于多药联合组 (6 9.2 %、6 9.2 %、6 9.2 % )。大于 31岁组化疗第 2、3、4、5、6日 ,奈西雅对食欲缺乏和恶心的完全控制率均明显优于小于或等于 31岁组。结论 :奈西雅能有效预防恶性血液病患者联合化疗所致的胃肠反应 ,不良反应轻 ,是良好的止吐药。每日重复用药不影响奈西雅的疗效 ,而化疗强度和年龄影响奈西雅的疗效。更多还原

【Abstract】 Objective: To evaluate the efficacy and safety of Nasea injection in the prophylaxis of gastrointestinal reaction induced by combined chemtherapy in patients with malignant blood diseases and to explore the influencing factors on the effect of Nasea. Methods: A repeated dose of Nasea at 0.3 mg or 5 μg/kg once daily was intravenously administered 15 minutes prior to combined daily chemotherapy to patient with malignant blood diseases. Results: The efficacy ratio of Nasea in the control of anorexia, nausea and vomiting was 84.2%～92.0%, 71.0%～92.0% and 90.3%～100%, respectively. The side effects of Nasea were mild. The efficacy ratio in the control of anorexia in the second day (100%), nausea (100%) and vomiting (100%) in the 12～18 hour period in the group of two antineoplastic agents was significantly superior to that in the group of multiple antineoplastic agents (69.2%, 69.2%, 69.2%). The complete response in the control of anorexia and nausea in the group of the age>31 years in the day 2,3,4,5,6 was significantly superior to that in the group of the age ≤31years. Conclusion: Nasea can effectively prevent the gastrointestinal reaction induced by combined chemotherapy in patients with malignant blood diseases and is an effective antiemetic agent. The effect of Nasea cannot be inhibited by daily repeated administration. The dose of antineoplastic agents and age can affect the effect of Nasea.更多还原