【摘要】 以 Taq I限制性内切酶测定 Fg基因的多态性与儿童单纯性肥胖进行关联研究 ,发现基因型的分布在单纯性肥胖组和正常体重组有显著差异 (基因型分布 P=0 .0 2 9;等位基因频率 P=0 .0 0 5 ) ,携带突变等位基因的儿童易于肥胖。从而推测 Fg基因可能是儿童单纯性肥胖的基因标记。研究结果提示 :通过测定基因基础不仅可以预测单纯性肥胖的倾向 ,而且可以为建立预防和干预肥胖的模型提供理论依据更多还原

【Abstract】 The association has been studied between fibrinogen(Fg) gene TaqI polymorphism and obese children. The genotype and alleles frequency are different significantly between obese children and controls and obese children have high risk with mutation alleles. It is suggested that Fg gene may be a genetic marker for obese children, which provides theoretical support for establishing a model of preventing and intervening obesity.更多还原