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正交试验法优化酸枣仁汤制备工艺

Optimization of Preparative Process of Suanzaoren Decoction by Orthogonal Design

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【作者】 李会军刘双跃李萍

【Author】 LI Hui jun 1, LIU Shuang yue 2, LI Ping 1 (1.China Pharmaceutical University, Nanjing 210038, China; 2.Sanye Pharmaceutical Co. Ltd, Haikou, Hainan 210038, China)

【机构】 中国药科大学!江苏南京570226海南三叶制药厂有限公司!海南海口570226

【摘要】 目的 :优选酸枣仁汤的最佳制备工艺。方法 :通过正交试验 ,以酸枣仁汤浸膏得率及酸枣仁汤浸膏中酸枣仁皂苷 A的含量为考察指标。结果 :选用药材粗粉 ,按处方比例混匀 ,先用水蒸气蒸馏法提取川芎挥发油 ,再加入总量为药材 8倍量的水 ,维持温度 95℃回流提取 2次 ,1h/次。结论 :本实验表明有效成分提取率高 ,稳定性好。

【Abstract】 Objective:To optimize the preparative process of Suanzaoren Decoction.Methods:The preparative process was observed by orthogonal design with extractive yield and content of jujuboside A as markers.Results:The optimum process was firstly distilling volatile oils of Rhizoma Ligustici Chuanxiong and mixing the course powder according to the prescription, adding 8 fold water, refluxing at 95℃ and extracting for 2 times, 1 h each time.Conclusion:This process shows higher yield of active constituents and good stability.

  • 【文献出处】 时珍国医国药 ,LiShiZhen Medicine and Materia Medica Research , 编辑部邮箱 ,2001年07期
  • 【分类号】R283.3
  • 【被引频次】8
  • 【下载频次】438
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