【摘要】 目的 :研究 2 -溴丙烷对大鼠睾丸的毒性。方法 :雄性成年 SD大鼠 40只 ,分为 1 80 0mg/ kg、6 0 0 mg/ kg、2 0 0 mg/ kg和对照组。腹腔注射 2 -溴丙烷 ,每日 1次 ,连续 5d。结果 :高剂量组大鼠体重下降 ,睾丸湿重和重量系数与对照组相比显著降低 ,而附属性腺的重量无显著改变。随着染毒剂量的增加 ,曲细精管损伤率升高 ( P<0 .0 5) ,精原细胞占曲细精管中生精细胞的比率显著降低 ,高剂量组大鼠的曲细精管面积减小。结论 :睾丸是 2 -溴丙烷生殖毒性的靶器官 ,2 -溴丙烷最早损伤精原细胞且毒作用最严重。更多还原

【Abstract】 WT5HZ]Objective: 2 bromopropane (2 BP) is considered as a kind of environmental endocrine disrupters (EDs). Its reproductive and hematopoietic toxicity has aroused the attention of international toxicologists during the past five years. In the present study, we aimed to determine experimentally the testicular toxicity of 2 BP in male rats. Materials & Methods: Forty SD male rats were divided into four groups of 10 rats each. The rats were intra abdominally administered 2 BP once per day for 5 d continuously at the doses of 1 800 mg/kg, 600 mg/kg, 200 mg/kg and normal saline, respectively. The rats were dissected one week after the first administration. Results: The body weight, absolute testes weight and relative testes weight of the rats in 1 800 mg/kg dose group decreased significantly with comparison to those of control group, while the weight of accessory gonads showed no significant change. With the increase of dosage, the seminiferous tubules damage rate aggravated while the ratio of spermatogonia in total germ cells fell with P <0.05. The seminiferous tubule area of rats in 1 800 mg/kg group also reduced significantly. Conclusion: The results indicated that testis was the target organ of 2 BP’s reproductive toxicity. The testicular toxicity of 2 BP started from damaging spermatogonia and its damage on spermatogonia was most obvious among all germ cells. [WT5HZ]更多还原