【摘要】 目的　研究鼻咽癌中P1 6 基因的状态。　方法　采用多重PCR分析法 ,单链构象多态性分析法 (SSCP)分别对湖南省 48例鼻咽癌标本与相应的癌旁组织中P1 6 基因突变情况进行了检测。　结果　 48例肿瘤标本中 ,发现 16例P1 6基因缺失点突变未检出 ,相应癌症组织缺失未检出。　结论　P1 6 基因在鼻咽癌中存在高频率的缺失 ,其改变在鼻咽癌发病过程中具有一定的作用。更多还原

【Abstract】 Objective To investigate the status of P 16 gene in nasopharyngeal carcinoma(NPC). Methods A total of 48 NPC samples and correspongant tumor-adjacent were detected for P 16 gene mutations by using multiplex polymerase chain reacion(PCR) and sigle strand conformational polymorphism(SSCP) respectively. Result Among 48 NPC samples,16 cases’ homozygous deletions and mulation were no idendtified.However, deletion and mutation were not found in all the tumor-adjacent tissues. Conclusion The data above show that P 16 gene loss in high frequency in nasopharyngeal carcinoma,The abnormal alteration of P 16 gene may play an important role in the nasopharyngeal carcinoma.更多还原