【摘要】 选用紫外分光光度计法 ,研究了静脉推注磺胺二甲嘧啶(SM2)后 ,在成年东北细毛羊体内的药物代谢动力学过程。主要药物代谢动力学参数:初始血药浓度(A)为(17.6359±2.57)mg·L -1,分布半衰期(t12α)为(0.3006±0.04)h,消除半衰期(t12β)为(4.6635±1.53)h,消除速率常数(β)为(0.1486±0.051)h-1,总清除率(CLB)为(0.6677±2.86)100mL·kg-1·h-1,中央室消除速率常数(Kel)为(0.2763±0.035)h -1,总表观分布容积(Vd)为(4.4933±0.37)100mL·kg-1 ,有效抑菌浓度维持时间(Tcp)为8.56h ,药—时曲线下面积(AUC)为(149.7732±19.45)mg·L-1·h-1。为此 ,确认磺胺二甲嘧啶(SM2)对东北细毛羊为短效药物。更多还原

【Abstract】 The Pharcokinetics of sulfamethazinum(SM2) in northeast thin-wool sheep were studied following intravenous injection by using spectrophotometer procedure. The main pharmacokinetic parameters were as A (17.6359±2.57)mg·L-1, tα(0.3006±0.04)h, tβ(4.6635±1.53)h, β(0.1486±0.051)h-1, CLB(0.6677±2.86)100mL·kg-1·h-1, Ke(0.2763±0.035)h-1,Vd(4.4933±0.37)100mL·kg-1, Tcp(ther)8.56h, AUC(149.7732±19.45)mg·L-1·h-1. The results suggest that SM2 is a short-time drug in northeast thin-wool sheep.更多还原