【摘要】 目的　研究老年帕金森病 (PD)患者抑郁与智能、病程、脑电地形图 (BEAM)、脑血流量 (CBF)和临床症状的相关性。　 方法 　 75例患者汉密尔顿抑郁量表 (HAMD)测试患者抑郁状态 ,长谷川简易智能评价分度表(HDS)测试患者智能 ,检查BEAM和13 3 Xe吸入法测定CBF ,并设正常对照组。　 结果 　伴抑郁PD患者 3 2例 ,占42 7% ,以运动迟缓和肌强直为主 ;无抑郁 43例 ,以震颤为主。伴智能障碍 2 9例 ,占 3 8 7% ;同时伴有抑郁和智能障碍 2 4例 ,占 3 2 %。HAMD值与HDS值、大脑平均血流量呈负相关 (r =-0 77、-0 71,P <0 0 1) ,与病程呈正相关(r =0 5 9,P <0 0 1) ,而与性别和年龄无相关性。伴抑郁PD患者双侧额叶、颞叶、顶叶和中央区脑局部血流量(rCBF)比无抑郁PD患者显著降低 (P <0 0 5～ 0 0 1) ,而该BEAM θ、δ相对功率显著增加 (P <0 0 5～ 0 0 1)。　 结论　PD患者抑郁与智能、病程、脑局部血流量和脑功能密切相关 ,而与性别、年龄无相关性更多还原

【Abstract】 Objective To study the relationship between depression and intelligence,duration of disease,brain electrical activity mapping(BEAM)?regional cerebral blood flow(rCBF)and clinical characteristics in the aged patients with Parkinsons disease(PD). Methods The intelligence and depression of 75 patients with PD were tested by Hasegawas Dementia Scale(HDS)and Hamilton Depression Scale (HAMD),and BEAM,rCBF(133Xe inhalation method) were examined. Results There were 32(42 7%)patients with PD who had depression,simultaneously 24 patients had abnormal intelligence,and these patients mainly showed movement retardation and paramyotonus;the other 43 patients with PD had no depression,and they mainly showed thrill.HAMD value was negatively correlated with HDS value and cerebral blood flow( r =-0 77?-0 71, P <0 01),and positively correlated with duration of disease ( r =0 59, P <0 01),and not correlated with sex and age.In double side frontal lobe and temporal lobe and parietal lobe of PD with depression,rCBF was lower and θ,δ of BEAM were higher than those without depression. Conclusions The depression of the aged patients with Parkinsons disease is obviously correlated with intelligence,duration of disease,regional cerebral blood flow and brain function,and not with sex and age.更多还原