【摘要】 目的　探讨性激素水平与阿尔茨海默病 (Alzheimer’sdisease ,AD)的关系。　 方法 　采用微粒子化学发光免疫法测定AD患者血清性激素 :黄体生成素、卵泡刺激素、催乳素、孕酮、雌二醇、睾酮的水平 ,并与健康老年组进行比较。　 结果 　女性AD患者血清中雌二醇含量 ( 15 13± 2 97)pg·ml-1明显低于对照组 ( 18 41± 2 91)pg·ml-1。　 结论　AD患者存在性激素失衡 ,尤其是女性AD患者雌激素水平降低明显 ,揭示了AD的发病与雌激素水平的降低可能有关 ,表明适当调节性激素水平可能有助于AD的防治。更多还原

【Abstract】 Objective To explore the relationship between Alzheimers disease(AD)and sex hormones. Methods Beck man coulter access immunoassay system was applied to detect the concentration of serum sex hormones,including luteinizing hormone,follicle stimulating hormone,prolactin,progesterone,estradiol and testosterone in the patients with AD and the healthy elderly control group as well. Results The serum estradiol level in female patients with AD(15 13±2 97)pg·ml -1 is lower than that in the control group (18 41±2 91)pg·ml -1 ( P <0 01). Conclusions The serum estradiol level decreases in female patients with AD.It suggests that the serum estradiol level play an important role in AD.Regulating the serum sex hormone level may be necessary in the treatment of AD.更多还原