【摘要】 目的　分析单纯X线立体定向放射治疗 (SRT)及附加全脑照射方法治疗脑转移瘤的疗效。方法　将 41例脑转移瘤共78个病灶分两组 ,2 4例行单纯SRT ,17例在术后附加全脑放疗 ;按病灶大小将本组 78个病灶分为大病灶 ( >3cm)和小病灶 ( <3cm )两组。全部病例于术后 2～ 19个月进行了CT随访。结果　单纯SRT组肿瘤治疗有效率 92 .9% ,SRT附加全脑放疗组为93 .7% ,大病灶组有效率 90 % ,小病灶组有效率 97.4% (Ρ >0 .0 5 )。单纯SRT肿瘤复发率为 2 5 % ,而附加全脑放疗为 5 .9% (Ρ <0 .0 5 )。 19.5 %术后出现放射性脑水肿。结论　SRT是脑转移瘤的一种有效的治疗手段 ,SRT附加全脑放疗能明显控制肿瘤的复发率 ,对于小于 3cm的转移瘤尤为适应更多还原

【Abstract】 Objective To evaluate the effect of X-ray stereotactic radiotherapy(SRT)with two different methods in curing brain metastases.Methods 41 patients with brain metastases were treated by SRT,including 24 cases by SRT and 17 cases by SRT combined whole brain irradiation.78 lesions in 41 patients fall into two groups:small tumor(<3 cm)and large tumor(>3 cm).All patients were followed for 2～19 months after treatment by CT scan.The effect,recurrent and complication were discussed.Results Following SRT,the effect rate was 92.9% in SRT group and 93.7% in SRT combined whole brain irradiation group.The effect rate was 97.4% for small lesions while 90% large lesions.The recurrent rate was much higher in SRT(17%) than that in SRT combined whole brain irradiation group(5.9%),the difference was statistically significant(Ρ<0.05).There were marked radiation edema in 8 cases after SRT,mainly appearing in large tumor group.Conclusion The short term follow up results show that SRT is an effective way for brain metastases with whole brain radiation,the recurrent rate was reduced and it is applicable in diameter less than 3 cm especially.更多还原