【摘要】 红细胞膜剪切弹性模量和表面粘度是表征红细胞膜粘弹性的两个重要指标 ,我们研究了动物受到 6 0 Co辐射后这两个指标的变化。通过对大白兔用 6 0 Co进行剂量为 7Gy的一次性全身均匀照射 ,采用了一种新型激光衍射法测量了红细胞在流场中的小变形指数和松弛过程中恢复半时间 ,从而计算出红细胞膜剪切弹性模量和表面粘度 ,经过照射后连续 6 0 d的动态观测 ,发现在照射后的 0～ 16 d,红细胞膜剪切弹性模量和表面粘度逐渐增大 ,16 d以后开始逐渐减小 ,6 0 d左右恢复稳定。造成这一变化趋势的原因可能在于辐射后兔子血液中的新老红细胞的比例以及红细胞膜的微观构象发生了改变更多还原

【Abstract】 RBC membrane shear elastic modulus and membrane viscosity are two important indexes reflecting RBC membrane viscoelasticity. Their variation was investigated in this study after rabbits were radiated with l 60 Co. With a new ektacytometer, we measured the small deformation index (DI d) and the half time of deformation relaxation (t 0.5 ) of RBC in flow field then we calculated RBC membrane shear elastic modulus and membrane viscosity. We found that the value of RBC membrane shear elastic modulus and membrane viscosity continuously increased from 0 to 16th day then continuously decreased and tended to be stable on 60th day or so. The reason may lie in the variation of proportion of new and old RBC in blood and variation of microconformation of RBC membrane after rabbits were radiated with 60 Co.更多还原