【摘要】 目的　探讨谷胱甘肽s 转移酶 μ基因 (Glutathiones transferaseμ ,gstμ)缺失与三硝基甲苯 (trinitrotoluene ,TNT)白内障发病的关系。方法　采用多聚酶链反应 (polymerasechainreaction ,PCR)方法 ,对TNT白内障患者、其他类型白内障患者、健康人群等 3组样本共 2 3 5人的DNA进行了gstμ基因检测。 结果　TNT白内障患者组gstμ基因缺失率高达 65 6% ,与各对照组比较差异均有显著性 (P <0 0 5 ) ,以健康人群为对照计算的gstμ基因缺失者发生TNT白内障的OR值为 2 3 3 ;gstμ基因缺失与TNT白内障的发生呈显著相关 (P <0 0 5 )。 结论　gstμ基因缺失与TNT白内障的发病有密切关系更多还原

【Abstract】 Objective To study the relationship between glutathione s transferase μ(gst μ)gene deletion and trinitrotoluene cataract(TC)susceptibility.Method Polymerase chain reaction(PCR)method was used to examine the rates of gst μ gene deletion in 154 cases of TC patients 41 cases of cataract patient by age or diabetes and 40 healthy persons.Results The rate of gst μ gene deletion in TC group was 68 58% which was significantly higher than that of other two groups——the non TNT cataract group(53 7%)and the healthy control group(45%)(P<0 05);the odds retio(OR)value based on the healthy control group is 2 33.Conclusion TC correlates closely with gst μ gene deletion,gst μ gene deletion may be one of the important hereditary factors for TC susceptibility.更多还原