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补肾益智方含药血清对培养海马神经元过度凋亡的抑制作用

Effect of Bushenyizhi Decoction on the Inhibition Mechanism of Apoptosis of Cultured Hippocampal Neuron

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【作者】 王怀星赖世隆

【Author】 Wang Huaixing (Shan dong University Jinan) Lai Shiling (Guangzhou University of TCM Guangzhou)

【机构】 山东大学基础医学院解剖教研室神经生物学研究室!济南 250012广州中医药大学第二临床医学院老年脑病研究所!广州 510405

【摘要】 目的:探讨天然促智药复方──补肾益智方含药血清对培养海马神经元过度凋亡的抑制作用。方法:取补肾益智方治疗组及各对照组大鼠的血清进行海马神经元培养,荧光标记,计量分析。结果:各组血清培养的海马神经元凋亡率,中药组明显低于模型组、石杉碱甲(HupA)组明显高于青年组,与老年正常组没有明显差异。结论:补肾益智方含药血清可减少培养海马神经元的过度调亡。

【Abstract】 OBJECTIVE: To explore the effect of complex prescription of natural nootropic drugs, Bushenyizhi decoction, on the inhibition mechanism of apoptosis of cultured hippocampal neuron. METHOD: Hippocampal neurons were cultured with the serum of the treated and the controls; and fluorescent labeling and statistics analysis were carried on. RESULTS: Apoptosis rate of the serum of treated was significant lower than that of the model and the Hup A, and higher than that of the young, CONCLUSION: The serum of the treated can inhibit the apoptosis of culture hippocampal neurons.

【基金】 国家“九五”重点科技攻关专题!(No96-906-09-02);教育部高校骨干教师基金;科技部生命科学发展中心博士基金!(No
  • 【文献出处】 世界科学技术 ,World Science and Technology , 编辑部邮箱 ,2001年01期
  • 【分类号】R285.5
  • 【被引频次】4
  • 【下载频次】101
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