【摘要】 目的　制备一种99mTc标记的心肌显像剂———99mTc 环己二酮肟配合物甲硼酸加合物 ,并对该显像剂99Tc的价态、99Tc的配位环境、放射化学纯度以及γ CD在药盒中的作用进行了研究。方法　使用X射线光电子能谱 (XPS)、纸层析法和循环伏安法 (CV)。结果　99Tc Teboroxime(由环己二酮肟、甲硼酸与SnCl2 还原了的99Tc形成的配合物 )是99Tc(Ⅲ ) ,且存在 :N99Tc和CL99Tc配位键。该配合物放置 6h ,XPS信号无明显变化。放置 8h ,99Tc3d5/ 2 的EB 值向高位能偏移 ,生成99Tc(Ⅳ )。其放化纯度较高且稳定 [平均放化纯度 (95 .19±3.13) % ]。此外 ,用循环伏安法显示 ,γ CD在药盒中有稳定的作用。结论　制备的心肌显像剂———99Tc 环己二酮肟配合物甲硼酸加合物是一种配位化合物 ,其稳定性良好 ,可供临床应用更多还原

【Abstract】 Purpose First to prepare a new technetium labeled myocardial imaging agent methane boronic acid adduct of 99m Tc cyclohexanedione dioxime Coordination Compound,Secondly to study the imaging agent’s oxidation state of 99m Tc,coordinational surronding of 99 Tc,radiochemical purity and the reaction of γ?cyclodextrin(CD) in kit.(teboroxime). Methods X ray photoelectron spectroscopy(xps),Paper chromatography and cyclic voltammetry(CV) were used in the experiments. Results The imaging agent was 99 Tc(Ⅲ),which had N 99 Tc and Cl 99 Tc coordinational bonds.The binding energy(Eb) value of 99 Tc 3d5/2 inclined to move to high potential energy as the coordination compound set down for 8 hours to form 99 Tc(Ⅳ) compound.Radiochemical purity of the coordination Compound was high and steady[average Radiochemical purity (95.19±3.13)%].In addition,γ?CD in kit(teboroxime) had the stability. Conclusions This new imaging agent is a coordination compound.It has good stability and can be supplied to clinical use.更多还原