【摘要】 花生四烯乙醇胺 (arachidonoylethanolamide,anandamide ,ANA)是近年来确定的大麻素受体的内源性配基 ,它主要分布在中枢神经系统、免疫系统及子宫等部位 ,具有大麻的主要活性成分———Δ9 四氢大麻酚 (Δ9 THC)的药理功能 .ANA有两种受体 ,即脑型受体 (CB1)和脾型受体 (CB2 ) ,它们都是与GTP偶联的跨膜受体 ,是ANA发挥作用的主要途径 .脂肪酸酰胺水解酶 (fattyacidamidehydrolase,FAAH)是ANA特异性极高的水解酶 ,它可以迅速调节ANA在体内的含量 ,从而发挥特异的生理作用 .更多还原

【Abstract】 Anandamide (N arachidonoylethanolamide), an arachidonic acid derivative, is an endogenous ligand for cannabinoid receptors, which are members of the G protein (Gi) coupled receptors family. Ananamide is mainly found in central nervous system, immune system and uterus etc and mimics most of the effects of (-)Δ 9 tetrahydrocannabinoid [(-)Δ 9 THC], a psycoactive derivative of marijuana. Fatty acid amide hydrolase (FAAH), which is involved in hydrolyzing anandamide to arachidonic acid and ethanolamide, may quickly regulate level of anandamide in vivo .更多还原