【摘要】 胎盘滋养层是直接与母体接触的与母体基因型不同的胎儿组织 ,滋养层细胞是否表达主要组织相容性复合体 (MHC)抗原以及表达何种MHC抗原对于妊娠成功与否至关重要 .非经典MHCⅠ类抗原发现较晚 ,其中HLA G在滋养层细胞表达 ,可以保护带有父方同种异体抗原的胎儿免受母体免疫系统的杀伤 .经典MHCⅠ类抗原有多种亚型 ,不同亚型在滋养层细胞的表达有所不同 .MHCⅡ类抗原在妊娠维持过程中表达极弱 ,新近的研究资料表明 ,滋养层细胞CⅡTA在MHCⅡ类基因表达调控中起主要作用 .更多还原

【Abstract】 The trophoblast is fetal derived and in direct contact with maternal tissues. The expression of the various types of MHC antigen in trophoblast cells is very important for successful pregnancy. Among nonclassical MHC class Ⅰ antigens, HLA G is expressed specifically on cytotrophoblast cells and its expression protects the fetal from maternal immune attack. The expression of the distinct subtypes of classical MHC class Ⅰ antigen is different in different subtypes of trophoblast cells. The expression of MHC class Ⅱ antigen is inhibited in trophoblast during pregnancy. It is suggested that CⅡTA plays an important role in regulation of MHC class Ⅱ gene expression.更多还原