【摘要】 目的　探讨细胞粘附分子和皮肤移植后排异反应之间的关系。方法　用ＨＥ及免疫组化方法观察２０例大鼠Ⅲ度烫伤异体－自体皮肤混合移植和１５例同种大鼠大张异体皮肤移植组织在移植后４～５，７，１４，２１和２８ｄ时细胞粘附分子ＩＣＡＭ－１和ＬＦＡ－１的表达情况。结果　大鼠Ⅲ度烫伤后异体－自体皮肤混合移植组织中ＬＦＡ－１＋淋巴细胞和ＩＣＡＭ－１＋细胞的表达均低于同种大张异体皮肤移植组织，与排异程度相一致，分别在移植后７和１４ｄ时差异显著（Ｐ＜０．０５）。结论　ＩＣＡＭ－１／ＬＦＡ－１不是主要促使皮肤混合移植排异反应中Ｔ细胞活化的共刺激信号，但ＩＣＡＭ－１＋细胞和ＬＦＡ－１＋淋巴细胞在介导同种大张异体皮移植排异反应中起主要作用。更多还原

【Abstract】 Objective To explore the relations between cell adhesion molecules and rejection to skin transplantation. Methods Using HE and immunohistochemical methods, we detected the ex- pression of cell adhesion molecules ICAM - 1 and LFA - 1 during 4 - 5, 7, 14, 21 or 28 days, respective- ly on 20 rats with intermingled transplantation of auto - alloskin and on 15 rats with large allo - skin transplantation after extensive full - thickness burns. Results The expression of LFA - 1 + lympho- cytes and ICAM - 1 + cells in the intermingled auto - alloskin grafts was lower than that of large allo - skin grafts with extensive full - thickness burns in rats, in the same line with the degree of rejection. The difference was significant (P < 0.05) on the 7th day and 14th day after transplantation respective- ly. Conclusion Neither ICAM - 1 nor LFA - 1 is the costimulatory signal that activated T - lympho- cytes in the rejection of intermingled auto - alloskin transplantation However, ICAM - 1 + cells and LFA - 1 + lymphocytes play a major role in the rejection caused by large allo - skin transplantation.更多还原