【摘要】 目的研究硒、VitC、VitE、β-胡萝卜素联用对小鼠细胞免疫功能及抗氧化功能的调节作用。　 方法随机分成五组 :对照组、剂量A组、B组、免疫抑制组、免疫抑制 +A组。每组小鼠分别喂饲不同剂量复合营养素 ,并测定它们的免疫功能和抗氧化功能。　结果研究发现每天补充A剂量复合营养素 (Se 1μg、VitC 1.2mg、VitE0 .2 4mg、β -胡萝卜素 0 .1mg)显著增强小鼠的淋巴细胞转化功能 ,增强脾细胞对IL - 2的反应活性以及提高NK细胞活性。超过一定的剂量 (Se 5 μg、VitC 6mg、VitE 1.2mg、β -胡萝卜素 0 .5mg)则表现出明显的免疫抑制作用 ( P <0 .0 1)。研究还发现Se、VitC、VitE、β -胡萝卜素联用在一定剂量内能对抗免疫抑制剂 (环磷酰胺 )的作用 ,刺激免疫功能低下的小鼠脾细胞产生IL - 2 ,增强淋巴细胞的转化功能 ,提高NK细胞活性 ,恢复受抑制的淋巴细胞产生IL - 2的能力。实验表明抗氧化营养素有双向的免疫调节作用。同时补硒可使小鼠肌肉及血清硒含量上升 ,补充抗氧化营养素可使小鼠血清及肝LPO浓度降低 ,肝SOD浓度升高。　结论一定剂量的Se、VitC、VitE、β-胡萝卜素联用可使小鼠的免疫及抗氧化功能提高。更多还原

【Abstract】 Objective Effects of a combined supplementation with selenium?vitamins C?E?β-carotene on the immunity and antioxidation of mice were studied. 50 mice were divided into five groups, and each group received a different dose of antioxidants for 20 days. It was found that the immune-normal mice feeded into dose A (Se 1μg?β-carotene 0.1mg,VitE 0.24mg,VitC 1.2mg) showed obvious enhancement in lymphocyte proliferation and activity of Natural killer (NK) cells and IL-2 (P<0.01). When the dose increased 5 times of the dose A, the immunity of the mice was significantly lower than the control group (P<0.01). The models of immune-suppressed mice were prepared by intra-peritoneal injection of cyclophosphamide. It was found that the immune-suppressed mice feeded dose A showed obviously enhancement in lymphocyte proliferation and greater NK cell and IL-2 activity, and liver LPO was correlated with serum IL-2 activity.更多还原