【摘要】 目的 :探讨原癌基因产物 β catenin与胃癌发生、分型以及侵袭转移的关系。 方法 :采用免疫组化SP法检测 10例胃粘膜肠化生、10例不典型增生及 4 9例胃癌标本中的 β catenin。 结果 :β catenin在正常胃粘膜和肠化生组织中表达均正常 ,在 1例不典型增生组织中表达丢失 ,在胃癌组织中异常表达率为55 10 %。浸润型胃癌异常表达率为 6 9 6 9% ,膨胀型 2 5% (P <0 .0 1)。无淋巴结转移者异常表达率为33 33% ,淋巴结转移者 6 4 71% (P <0 .0 5)。无远处转移者 50 % ,有远处转移者 10 0 % (P <0 .0 5)。结论 :β catenin与胃癌发生、Ming’s分型密切相关 ,是肿瘤获得高侵袭转移潜能的重要原因之一。更多还原

【Abstract】 Objective:To study the relationship between β catenin expression and carcinogenesis of gastric mucosa,classification,and metastasis in gastric carcinoma.Methods:The β catenin expression was examined immunohistochemically in normal gastric mucosa,metaplasia,dysplasia and carcinoma with β catenin antibody.Results:It was showed that β catenin expression was normal in gastric mucosa and metaplasia.Up to 10% of gastric dysplasia and 55.10% of tumors stained abnormally for β catenin(P<0.01).Abnormal β catenin staining occurred more frequently in infiltrative type than expanding type tumors(P<0.05).Tumors with regional nodal metastasis showed significantly higher abnormal staining rate(64.71%) than those without nodal involvement(33.33%)(P<0.05).Abnormal β catenin expression in tumors with distant metastasis(100%) was statistically different from those without distant metastasis(50%)(P<0.05).Conclusion:The abnormal expression of β catenin is correlated with carcinogenesis and classification,and is an important factor for development of the highly invasive potentials in tumors.更多还原