【摘要】 目的 评价奎的平对难治性精神分裂症的疗效与副反应。方法 对住院的难治性精神分裂症60例换用奎的平治疗24周。用阳性和阴性症状量表(PANSS)评定疗效,用副反应量表(TESS)及锥体外系副反应量表(ESRS)评定副反应。结果 PANSS总分、PANS-G(一般精神病理)分、PANSS-P(阳性症状)分、PANSS-N(阴性症状)分治疗前后有显著意义。PANSS总分及各分量表分均自12周末起有显著下降,说明自12周末开始显效。PANSS总分减分率≥20％者36例,≥50％者10例,有效率为60％。显效率为16.67％。最常见的副反应是体重增加(18/60)。结论 奎的平对难治性精神分裂症有肯定的疗效,副反应轻微。更多还原

【Abstract】 Objective To studyy the clinical efficacy and side effects of quetiapine in the treatment of refractory schizophrenic patients. Methods Sixty inpatients with poore response to traditional psychotomimetic or clozapine before this study were switched to quetiapine 300 ~ 700mg/d for 24 weeks.The positive and negative symptoms scale (PANSS) was used to evaluate the efficacy,while the treatment emergent symptom scale (TESS) and the extrapyramidal symptom rating scale (ESRS) were used to assess the side effects.Results After the treatment,the scores of PANSS,PANSS- G (general psychotic symptom), PANSS - P( positive symptom) and PANSS - N( negative symptom) were significantly de^ creased. The main side effect was slight weight increment. Conclusion Quetiapine is an effective and safe novel antipsy-chotic in the treatment of refractory schizophrenia,though about 30% (18/60) cases may appear slight weight increment.更多还原