【摘要】 目的:评价中药AY注射液对吗啡依赖性小鼠、大鼠催促戒断的治疗作用。方法:用扭体法、热板法致痛考察中药AY注射液镇痛作用,并且以剂量递增方法形成吗啡依赖模型,用纳洛酮催促戒断。结果:中药AY注射液无显著镇痛效应,注射液大、中、小剂量(10.8g/kg、5.4g/kg、2.7g/kg)均能减轻小鼠注射纳洛酮后跳跃反应,但只有小剂量组可以减轻小鼠体重下降。结论:中药AY注射液能明显抑制大鼠的戒断反应,其中中药AY注射液大、中、小剂量能明显抑制大鼠异常姿势、激惹、咬牙、流泪、腹泻、流涎等症状(评分值P<0.05～0.001);均能明显抑制大鼠体重下降(P<0.05～0.01)。更多还原

【Abstract】 In this study, the anagesic effect of AY herb injection was found with hot plate method and torsion body method. On this base, the mice and rats Morphine-dependent model were established respectively for the evaluation of the detoxication effect of AY herb injection. Naloxone was given to animals to makre them appear abstinence symptoms. The rresults show that AY herb injection have an obvious inhibiting effect of abnormal posture, irritation, bry-mas lachrymation, diarrhoea, salivation and lose of body weight on rats.更多还原