【摘要】 该文采用 Fe Cl3局部涂抹损伤血管造成的大鼠大脑中动脉血栓模型 ,以脑梗塞范围、行为障碍、脑组织病理改变为观察指标 ,研究 989对脑血栓所致局部缺血性脑损伤的保护作用。结果表明 :9895.0、10 .0 mg/ kg手术后 30 min舌下静脉注射能明显缩小脑栓塞大鼠 2 4 h后的脑梗塞范围 ;98910 .0 mg/ kg能明显改善脑栓塞大鼠的行为障碍。脑组织病理检查发现 ;98910 .0 mg/ kg组动物大脑中动脉内血栓形成极少或未形成 ,脑组织缺血病变较轻。表明 989对栓塞性脑损伤具有明显的保护作用更多还原

【Abstract】 The protective effects of 989 on cerebral ischemia induced by FeCl 3 in rats with cerebral middle artery (CMA) occlusion were investigated in this study. The results showed that 989 at a doses of 5.0 and 10.0 mg/kg via sublingular vein injection decreased the cerebral infarction area and 989 at a dose of 10.0 mg/kg improved the disbalance of behavior. Also, a significant difference existed between 989- treated group at the dose of 10.0 mg/kg and the FeCl 3 treated group on inhibiting the thrombosis embolic in CMA(p<0.01). Our data suggested that 989 exerted a protective action on cerebral ischemia induced by thrombosis in rats.更多还原