【摘要】 在对文献报道的间三氟甲基苯胺合成路线进行试验和分析对比的基础上 ,开发了以甲苯为起始原料 ,经催化氯化和氟化、变温硝化、低压液相催化加氢还原和精馏提纯生产含量达 99%以上的间三氟甲基苯胺新工艺 ,以甲苯计总收率为 73.1%。更多还原

【Abstract】 A process for the manufacture of m-(trifluoromethyl)aniline by catalytic chlorination of toluene, followed by catalytic fluorination in liquid phase , nitration, and hydrogenation in the presence of Raney Ni was described. The total yield was 73.1% and the purity of the product was 99% over.更多还原