【摘要】 目的　了解碱化丁吡卡因在胸段硬膜外麻醉中的临床效果及副作用。　方法　 6 0例乳腺癌手术病人被随机分为 2组 ,每组 30例 ,用不同 pH值的 0 .2 5 %丁吡卡因行硬膜外麻醉 ,观察麻醉的潜伏期、作用完全期和维持期 ,并记录碱化组麻醉前后的心率、血压、动脉血氧饱和度、每分钟通气量和呼吸频率 ,加以对比。　结果　碱化组的麻醉潜伏期和作用完全期均比对照组明显缩短 ,但麻醉的维持期无显著差异。碱化组麻醉后的心率和血压都有明显下降 ,但都在正常范围内 ,呼吸功能无明显变化。　结论　 0 .2 5 %碱化丁吡卡因用于胸段硬膜外麻醉能明显缩短麻醉的诱导时间 ,弥补了其起效慢的缺陷 ,且对循环、呼吸系统功能影响较小更多还原

【Abstract】 Objective To study the effect and side effect of 0.25% carbonated bupivacaine for thoracic epidermal anesthesia. Methods 60 patients with breast cancer were divided into 2 groups. 0.25% carbonated bupivacaine (pH=7.12) was used in group I.The same concentration but lower pH value (5.40) was used in group Ⅱ.The period of incubation,whole effect and maintenace were observed in 2 groups.Heart rate ,blood pressure,SpO 2,ventilation volume per minute and respiratory rate were measured before and after anesthesia in group I. Results The period of incubation and whole effect in group I were much shorter than group Ⅱ,but the maintenace period did not prolong in group I. After anesthesia ,the heart rate and the blood pressure fell sharply in group I,but the functions of circulation and respiration were still normal. Conclusions 0.25% carbonated bupivacaine could obviously shorten the induction period but both the functions of circulation and respiration were affected slightly for thoracic epidural anesthesia.更多还原