Objective: To investigate the effects of TMP on plasma ET-1 and CGRP of glomerulur disease. Method: The patients with glomerular disease were randomly assigned to TMP treatment group and control group(without using TMP).Plasma ET-1and CGRP were measured before and after the treatment. Result: In the study TMP not only reduced plasma ET-1 ,but also increased plasma CGRP significantly. Conclusion: TMP has a renoprotective effect on renal function by reducing ET-1 and increasing CGRP.