【摘要】 目的 :观察原发性骨恶性淋巴瘤 (PLB)的临床病理及免疫表型特征。方法 :对 8例PLB进行临床病理学观察及免疫组织化学染色 (ABC法 )。结果 :8例PLB平均年龄 5 1岁。X线片示溶骨性破坏或伴有骨质疏松 ;组织学观察均为弥漫性非霍奇金淋巴瘤 (NHL) ,大细胞性 4例、中心细胞性 2例、混合细胞性 (中心细胞 中心母细胞 )和淋巴浆细胞样各 1例 ;免疫组化显示B细胞 6例、T细胞 2例。结论 :PLB好发于 5 0岁左右 ,X线片主要表现为溶骨性破坏和骨质疏松。病理类型为弥漫性NHL ,细胞形态主要是大细胞 ,免疫表型则以B细胞多见。免疫组化有助于PLB的鉴别诊断更多还原

【Abstract】 Purposes To observe the clinicopathologic and immunohistochemical features of primary lymphoma of bone(PLB). Methods Eight cases of PLB were investigated by light microscopy and immunohistochemical staining. Results The mean age of eight cases of PLB was 51 years. Radiographs of all cases showed the lytic lesions or osteoporosises; All the cases were diffuse non Hodgkins lymphomas(NHL), including 4 large cell lymphomas (centroblastic, CB), 2 centrocytic(CC), one mixed cell (CB CC ) and one lymphoplasmacytic (LP); Immunohistochemical features revealed 6 cases of B cell, 2 T cell. Conclusions The peak incidence for PLB is in the 5th decade with the radiologic appearance of lytic lesions or osteoporosises. All tumors are the diffuse NHL, including mainly large cell lymphomas and immunophenotypic features of B cell lymphomas. Immunohistochemistry is helpful in the differential diagnosis of PLB.更多还原