【摘要】 目的：探讨白塞病的临床特点及实验室改变。方法：对６４例 ＢＤ患者的临床及实验室资料进行统计分析。结果：口腔溃疡６１例，外生殖器溃疡４４例，眼部损害２１例，皮肤损害３３例，针刺反应阳性３９例。首发症状以口腔溃疡最常见（４２例）。６例并发心血管系统损害，５例并神经系统损害，１例并急性肾功能衰竭，１例并食道下段溃疡并出血；实验室检查有多项免疫学指标的异常，１２例检测到自身抗体（１２／４０）；皮肤及粘膜组织活检病理改变均符合小血管炎症。结论：白塞病是累及全身多系统器官以血管炎改变为基础的免疫性疾病，皮质类固醇激素或激素并免疫抑制剂治疗有较好的临床疗效。更多还原

【Abstract】 Objective: To explore the clinical features and laboratory changes of Behcet’s disease. Methods: Analyzed the clinical and laboratory data from 64 patients with Behcet’s disease. Results; O-ral ulcer was found in 61 cases, genital ulcer in 44 cases, ocular involvement in 21 cases, cutaneous lesions in 33 cases. Needling reaction in 39 cases. Oral ulcer often was the initial clinical sign. Cardiovascular lesions was complicated in 6 cases, neurologic manifestations in 5 cases, acute renal insufficiency in 1 case, ulcer situated in lower end of esophagus resulted in bleeding in 1 case. Several im-munologic findings were abnormal. Autoantibodies were detected in 12 of 40 patients, Histopathological examinations of skin and mucous membrane biopsies revealed vasculitis affecting small vessels. Conclusion; Behcet’s disease is an autoimmunologic disorder involved multisystem in which vasculitis is underlying histopathologic changes. Steroids or immunosuppressive agent with steroid combined were good respo nse.更多还原