【摘要】 目的 探讨载脂蛋白E(apoE)基因多态性与早期脑梗塞复发的关系。方法 将年龄55～75岁之间脑梗塞患者分为早期复发性脑梗塞与普通脑梗塞,和对照组三组分别以聚合酶链反应限制性片段长度分析法 (PCR -RFLP)检测apoE基因型。 结果 对照组apoE基因型以ε3/3最多,其次ε2/3,二组脑梗塞也以ε3/3最多,其次为ε3/4。二组病例ε3/4基因型、ε4等位基因频率均显著高于对照组,尤以早期复发性脑梗塞组为突出,且其ε4等位基因频率明显高于普通脑梗塞组。结论 ApoEε4基因是脑梗塞的危险因素,并与脑梗塞早期复发有关更多还原

【Abstract】 Objective To study the relationship between polymorphism of apolipoprotein E (apoE) gene and early recurrent cerebral infarction. Methods 56 early recurrent and 60 non-recurrent patients of cerebral infarction, and 40 normal controls were included. PCR-RFLP was used to detect the apoE genotype. Results The apoE ε 3/4 genotype frequency and ε 4 allele frequency of the two cerebral infarction group were higher than those of controls, and there was significant difference in ε 4 allele frequency between the early recurrent (26.79%) and non-recurrent patients (15.00%). Conclusion The study suggested that apoE allele could be regarded as a risk factor for the onset and early recurrence of cerebral infarction.更多还原