【摘要】 用微弱化学发光法和酶联分光光度技术研究胃癌高发区——甘肃省武威地区不同人群血浆总抗氧化力 ( TRAC)和谷胱甘肽过氧化物酶 ( GSH- Px)活性 .结果表明 :中度表浅性胃炎 18例、重度表浅性胃炎 2 1例、萎缩性胃炎 17例、胃癌 35例和食管癌 2 0例血浆 TRAC均较正常对照组2 1例明显降低 ( p≤ 0 .0 1) ,但各组间血浆 GSH- Px活性无显著性差异 ( p >0 .0 5) .提示当地胃癌高发可能与血浆 TRAC水平的降低有关 ,而与 GSH- Px活性改变无明显相关 .更多还原

【Abstract】 By chemiluminescence assay and enzyme-linked spectroscopic analysis, the total radical-trapping antioxidative capacity (TRAC) and glutathione peroxidase (GSH-Px) activity of plasma were studied in various examined subjects of the area, Wuwei County of Gansu Province in Northwest China, with a high mortality of gastric cancer. The results showed: TRACs in moderate chronic superficial gastritis (N=18, 7.6±6.0, p<0.01), severe chronic superficial gastritis (N=21, 7.9±7.5, p=0.01), atrophic gastritis (N = 17, 5.1±4.4, p<0.001), gastric cancer (N=35, 3.0±2.1, p<0.001) and esophageal cancer groups (N=20, 3.6±2.5, p<0.001) were significantly lower than that of control group (14.9±9.9). But the GSH-Px activity of plasma had no significant statistic difference with each group. These results suggest that the TRAC fault may be involved in the high-risk of gastric cancer examined area while the GSH-Px activity is not conspicuously concerned with gastric carcinogenesis.更多还原