【摘要】 [目的 ]评估氯乙烯累积接触剂量和氯乙烯职业危害的关系。[方法 ]选取某厂 2 3 8名职业接触氯乙烯人群和 2 12名非接触人群 ,登录该厂历年氯乙烯浓度监测资料 ,以及工人健康监护资料 ,将暴露人群按累积接触剂量分为未接触组和低、中、高接触组 ,比较接触组间和接触组与对照组间工人的症状和体征方面的差异。[结果 ]神经症、肝B超异常及咽部刺激症状随氯乙烯累积接触剂量的升高 ,发生率有升高的趋势 (P <0 0 1) ,与对照组比较也有显著性差异。[结论 ]咽部刺激症状和肝脏的损害均与接触氯乙烯有明显的关系。提示在我国的卫生标准范围内 ,氯乙烯仍可能产生一定的健康危害。更多还原

【Abstract】 Objective] The study was to evaluate the relationship between the accumulated exposure dosage and the occupational health hazard in workers exposed to vinyl chloride monomer (VCM). [Methods] 238 VCM exposed workers were selected as an exposed group while 212 unexposed workers as a control group. Entering the data of VCM concentration for 10 years and data of worker health status,and computing accumulated exposure dosage for each worker,and classifying the exposed workers into higher,middle and lower subgroups according to the dosage were carried out. Then,the frequency of symptoms and signs between the exposed group and the control group and among three subgroups of the exposed group was compared. [Results] The increase in incidence of the nerve debility syndrome and B ultrasonic of liver abnormality and the irritation symptom of pharynx appeared with the increase of VCM accumulated exposure dosage (trends χ 2 test, P <0 01 or 0 05). The frequencies of the symptoms and signs between the exposed group and the control group are remarkably different ( P <0 01 or 0 05). [Conclusion] There is significant relationship between VCM exposure and liver hazard and the irritation symptom of pharynx. VCM will cause health hazardous effects in the exposed workers even to the concentration lower than the health standard (MAC) of China.更多还原