【摘要】 目的 :通过测定血浆降钙素基因相关肽 ( CGRP)、内皮素 ( ET- 1)和血清一氧化氮 ( NO)不同时间的含量变化 ,研究重组葡萄球菌激酶溶栓对急性心肌梗死 ( AMI)血管再通的影响。方法 :采用放免法及比色分析法对再通组 3 5例 ,未通组 2 5例及正常组 3 0例的 CGRP,ET- 1和 NO含量进行测定。结果 :再通组溶栓后 1h血浆 CGRP浓度 ( 2 2 0 .87± 3 5 .98) ng/ L达峰值 ,是溶栓前的 4倍以上 ;未通组各时间点 CGRP含量均低于再通组 ,溶栓后 1,3 h与再通组比较差异有高度统计学意义 ( P均 <0 .0 1) ;2处梗死者的 CGRP浓度峰值 ( 10 2 .3 3± 3 4 .89) ng/ L 较 1处梗死者 ( 14 5 .79± 4 5 .69) ng/ L 明显降低 ( P<0 .0 5 ) ;再通组 ET浓度较未通组明显升高 ( P<0 .0 5 )。结论 :AMI溶栓早期 CGRP和 ET浓度明显升高可能与梗死相关动脉再通有关更多还原

【Abstract】 AIM: To observe the changes of contents calcitonin gene related peptide (CGRP),endothelin 1 (ET 1) in plasma and serum nitric oxide (NO) level before and after recombinant staphylococcus kininase (r Sak) thrombolysis therapy in patient with acute myocardial infarction (AMI). METHODS: The patients with AMI were divided into 2 groups: reperfusion group (group A, n =35) and non reperfusion group (group B, n =25). Radioimmunoassay (RIA) was used to measure the plasma CGRP and ET in patients and control group, and colorimetric analysis method was used to measure the serum NO levels. RESULTS: The content of CGRP of the reperfusion group was generally higher than that of control group, after 1 h later of thrombolysis while the consistency CGRP of the blood plasma reached the peak value of (220 87±35 98) ng/L, that 4 times than before thrombolysis, non reperfusion group’s content of CGRP was generally lower than reperfusion group in cirresponding moment, 1 and 3 h after thrombolysis, it had significance differences ( P <0 01) to compare with the reperfusion group; the peak value (102 33±34 89) ng/L of CGRP of the 2 place of AMI was lower abviously than 1 place of AMI patient ( P <0 05) (145 79±45 69) ng/L; contents of ET of the reperfusion group was generally higher than those of non reperfusion group ( P <0 05). CONCLUSION: The obvious rise of the concentration of the CGRP, and ET in earlier AMI antithrombolysis shows that therapy relationship with artery would be reperfusion.更多还原