【摘要】 比较具有不同药理学特性的血管紧张素受体拮抗剂缬沙坦和氯沙坦;在轻中度原发性高血压中的抗高血压疗效。方法:40例患者随机接受缬沙坦80mg;qd或氯沙坦50mg;qd;持续治疗4wk;然后缬沙坦组和氯沙坦组互换药物接受4wk的治疗。治疗期间每隔2wk对患者进行24h动态血压监测;并测量患者的偶测血压和心率。结果:氯沙坦和缬沙坦都具有明确的抗高血压疗效。和氯沙坦相比;缬沙坦显示出更良好的抗高血压效果。结论:在抗高血压效果方面不同的血管紧张素受体拮抗剂的药代学和药动学差异具有潜在重要性。更多还原

【Abstract】 AIM: To compare the clinical efficacy of 2 angiotensin Ⅱ receptor antagnisms (valsartan and losartan) with different pharmacological characteristics in the treatment of mild moderate primary hypertension. METHODS: Forty selected patients were treated at random with valsartan or losartan once a day, the doses were respectively 80 mg and 50 mg. After 4 wk, the 2 groups treatment were exchanged. During drugs therapy, the patients’s abulatory blood pressure monitoring (ABPM) and measured accidental blood pressure (BP), heart rate (HR) were measured once every 2 wk. RESULTS: Both valsartan and losartan had definite efficacy in the treatment of primary hypertension. Then, compared with losartan, valsartan was superior. CONCLUSION: Difference of pharmacodynamics and pharmacokinetics of angiotensin Ⅱ receptor shows its potential importance in antihypertensive treatment.更多还原