【摘要】 目的:探讨CD44v6基因在宫颈癌组织中的表达情况及其临床意义。方法:用免疫组织化学S-P法,检测56例宫鳞癌,32例宫颈腺癌中CD44v6蛋白的表达情况并分析相关的临床病理因素。结果:CD44v6表达与宫颈癌组织学类型无关;无论宫颈腺癌或鳞癌,淋巴结转移组中CD44v6阳性表达明显高于无淋巴结转移组（P<0.05）;CD44v6表达与宫颈癌临床分期、病理分级、病灶大小无关（P>0.05）。结论:CD44v6在宫颈癌淋巴结转移及癌细胞分化过程中可能起着重要作用,对早期预测癌细胞的转移潜能、判断宫颈癌预后具有一定的临床意义。更多还原

【Abstract】 Objective: To study the clinical significance of expression of CD44v6 in cervical cancer. Methods: Immunohistochemical stain was used to determined the expression of CD44v6 in biopsy specimen of 56 squamous carcinomas and 32adenocarcinomas. Results: No close correlation was observed between the positive expression of CD44v6 and the pathological type in cervical cancer. The CD44v6 expression in cases with lymph node involvement was significantly higher than without. There was no association between CD44v6 expression and clinical stage、pathological grade、tumor size. Conclusions : The date suggest that the expression of CD44v6 is of significance in predicting the potential cancer metastasis.更多还原