【摘要】 目的 :探讨 p5 3基因突变在血液系统肿瘤发病及进展中的作用。方法 :采用 PCR- SSCP方法对 34例血液系统肿瘤患者 p5 3基因第 5、8外显子进行研究。结果 :从 1例急性粒细胞白血病 (AML ) (1/ 12 ,8.33% ) ,1例急性淋巴细胞白血病 (AL L) (1/ 5 ,2 0 % ) ,2例非霍奇金淋巴瘤 (NHL) (2 / 5 ,40 % ) ,2例多发性骨髓瘤 (MM) (2 / 8,2 5 % )中发现了 p5 3基因突变。其中 1例 AML,1例 NHL 及 1例 MM,均在检测后 3个月内死亡。结论 :p5 3基因突变在血液系统肿瘤的发病及疾病发展中起着一定的作用更多还原

【Abstract】 Objective:To discuss the role of p53 gene mutations in the pathogenesis of hematologic malignancies.Method:Exon 5、8 of the p53 gene were scanned in 34 cases of hematologic malignancies by PCR SSCP.Result:p53 gene mutations were detected in 1 of 12( 8.33 %)patients with acute myelogenous leukemia(AML),1 of 5(20%) with acute lymphoblastic leukemia(ALL),2 of 5 (40%)with non Hodgkin′s lymphoma(NHL) and 2 of 8 (25%) with multiple myeloma( MM),in which one case of AML,one case of NHL and one case of MM died in three months after detection.Conclusion:The p53 gene mutations plays a certain role in the pathogenesis and progression of hematologic malignancies.更多还原