【摘要】 目的　探讨慢性肺心病患者凝血功能变化的临床意义。方法　测定 40例慢性肺心病患者急性加重期治疗前、后血浆凝血因子Ⅷ相关抗原 (ⅧR∶Ag)、因子Ⅷ凝血活性 (Ⅷ∶C)、抗凝血Ⅲ酶抗原 (AT Ⅲ∶Ag)、抗凝血酶Ⅲ活性 (AT Ⅲ∶A)、纤维蛋白原含量 (Fbg)及D 二聚体 (D D)的变化。结果　慢性肺心病患者急性发作期血浆反映凝血功能的指标ⅧR∶Ag、Ⅷ∶C及Fbg含量均明显增高 (P <0 .0 1 ) ;反映抗凝血功能的指标AT Ⅲ∶Ag和AT Ⅲ∶A均明显降低 ( P <0 .0 1 ) ;纤溶指标D dimer明显增高 (P <0 .0 1 )。治疗缓解期各项指标均明显恢复 ,但仍未达正常水平 (P <0 .0 5)。结论　慢性肺心病急性加重期存在血液高凝状态及抗凝血功能障碍 ,肺心病急性加重期应重视抗凝治疗。更多还原

【Abstract】 Objective To investigate the clinical signification of coagulation abnormality in patients with cor pulmonale. Methods The ⅧR∶Ag, Ⅷ∶C, AT Ⅲ∶Ag, AT Ⅲ∶A, Fbg and D Dimer of plasma in 40 patients with cor pulmonale during acute attack were detected before and after treatment. Results The levels of ⅧR∶Ag, Ⅷ∶C, Fbg and D Dimer in plasma of the patients were significant higher, and AT Ⅲ∶Ag, AT Ⅲ∶A were significant lower than that in normal subjects during acute attack(P<0.01). All these index had regain after treatment, but also abnormal contrast with normal subjects(P<0.05). Conclusion The activity of blood coagulation increased, and the function of anticoagulation decreased in patients with cor pulmonary. It is very important to treat the patients with cor pulmonale during acute attack by anticoagulation.更多还原