【摘要】 目的　探讨激素依赖 ( SD)型哮喘临床特征和单个核细胞 ( PBMC)糖皮质激素受体 ( GR)的水平。方法　 2 6例激素依赖型哮喘 ,口服泼尼松 2 0 mg/ d,7天 ,依据肺功能的变化 ,分为激素敏感 ( SS)型哮喘 11例和激素抵抗 ( SR)型哮喘 15例 ,比较两型临床、肺功能和 PBMC的 GR水平。结果　SS型和 SR型哮喘在病史、肺功能和血嗜酸粒细胞方面差异无显著性 ,SR型哮喘患者PBMC的 GR水平明显低于 SS型哮喘患者 ( P<0 .0 0 2 )。结论　激素依赖型哮喘包括 SS型和 SR型哮喘 ,SR型哮喘 GR水平异常低下是其特征更多还原

【Abstract】 Objective To investigate the clinical characteristics and glucocorticoid receptor in peripheral blood mononuclear cells of steroid depentent asthma(SD).Method 26 patients with SD asthma,taken in prednisone 20mg/d for 7 days ,were dividided into two groups;(1) 11 patients with steroid sensitive(SS)asthma;(2) 15 patients with steroid resistant(SR)asthma according to pulmonary function.Clinical data,baseline pulmonary function and glucocorticoid receptor were compared between the two groups.Results There was no significant difference between SR and SS asthma in history?pulmonary function and eosinphils,but the number of GR in PBMC from SR asthmatics was significantly less than that from SS asthmatics(P<0.002).Conclusion (including SS and SR asthma),The low glucocorticoid recepter is the characteristic of SR asthma.更多还原