【摘要】 目的 :研究原发性中耳癌人类乳头状瘤病毒 (H PV) DNA的表达情况。方法 :采用多聚酶链反应技术 ,对 5例中耳癌的病理组织蜡块进行 HPV - DNA类型的检测 ,以 8例慢性化脓性中耳炎中耳乳突粘膜为对照组。结果 :5例中耳癌高危型 HPV感染率为 80 % (4 /5 ) ,以 HPV1 6型感染为主 ,而对照组 HPV感染率为 0 % (0 /8) ,经 χ2检验 ,P <0 .0 1。结论 :中耳癌高危型 HPV感染率较高 ,慢性化脓性中耳炎和中耳胆脂瘤以及 HPV感染可能在中耳癌的发生发展中起着重要作用更多还原

【Abstract】 Objective:To study the expressions of human papillomavirus DNA in the middle ear carcinomas.Method:A PCR method using consensus primers for the detection of HPV 6,11,16,18 was applied in 5 biopsies of middle ear carcinomas.Eight biopsies of mucosa in middle ear and mastoid were concluded as controls.Result:It was found that a resulting 80%(4/5) of the middle ear carcinomas contained high risk type HPV DNA, while the 0%(0/8)of the controls. Conclusion:The high prevalence of high risk type HPV in carcinomas of the middle ear suggests that viral infections may be an important etiologic component in the carcinogenic process.更多还原