【摘要】 为探讨清开灵注射液的解热机制 ,建立家兔内毒素 (ET)性发热模型 ,观察清开灵对发热家兔体温的影响和下丘脑、脑脊液cAMP及隔区AVP含量的变化。结果显示 ,ET组的ΔT、TRI1、下丘脑cAMP含量、脑脊液cAMP含量、隔区AVP含量显著高于生理盐水组及清开灵注射液 +ET组 ,下丘脑、脑脊液cAMP含量变化与体温变化呈正相关。 4组隔区AVP含量变化亦与体温变化呈正相关。说明清开灵能够抑制ET性发热家兔的体温升高 ,在降低下丘脑、脑脊液cAMP水平的同时促进隔区释放精氨酸加压素 (AVP)。这可能是清开灵解热的重要机制之一。更多还原

【Abstract】 The effects of Qingkailing Injection on body temperature, on the level of cAMP in hypothalamus and cerebrospinal fluid and on the level of arginine vasopressin in ventral septal area, were observed in endotoxin fevered rabbits, in order to study the antipyretic mechanisms of Qingkailing Injection. The results showed that the levels of ΔT and TRI 1, the level of cAMP in hypothalamus and cerebrospinal fluid, and the level of arginine vasopressin in ventral septal area in endotoxin given rabbits, were higher than those in the rabbits given normal saline or given Qingkailing Injection plus endotoxin, with a positive correlation between body temperature and the level of cAMP in hypothalamus and cerebrospinal fluid. The results also showed that there was a positive correlation between body temperature and the level of arginine vasopressin in ventral septal area in all animals in the experiment, which implies that lowering the level of cAMP in hypothalamus and cerebrospinal fluid and at the same time promoting the release of arginine vasopressin in ventral septal area, may be an important antipyretic mechanism of Qingkailing Injection.更多还原