【摘要】 采用早老龄小鼠 ,制备脑缺血再灌合并尾部放血降压致学习记忆功能障碍拟血管性痴呆模型。通过避暗试验、水迷宫试验和脑组织病理形态学 ,观测了聪圣胶囊对模型小鼠学习记忆和脑病理损伤的改善作用。实验结果表明 ,采用双侧颈总动脉反复缺血再灌合并尾部放血降压的方法可明显降低早老龄小鼠的学习记忆能力 ,给药 4 5d后 ,聪圣胶囊各剂量均可使小鼠学习记忆障碍程度得到改善 ,并可减轻脑组织病理损伤程度。更多还原

【Abstract】 Presenile mice were used to establish the vascular dementia model characterized by disturbance in learning and memorizing by the method of cerebral ischemia reperfusion and blood pressure reduction through tail bloodletting. The therapeutic effects of Congsheng Capsules (CC) on disturbance in learning and memorizing and cerebral pathological injuries were observed. The results showed that the learning and memorizing abilities could be obviously decreased by performing repeated ischemia reperfusion of bilateral common carotid artery and reducing blood pressure through tail bloodletting; after the treatment of CC in different doses for 45 days, it was found that to a certain degree, every dose of CC could improve the learning and memorizing abilities and reduce the cerebral pathologic injuries.更多还原