【摘要】 目的 :了解黄芪对肾病综合征大鼠的治疗作用。方法 :选Wistar大鼠 2 4只 ,8只作为正常对照 ,余一次性尾静脉注射盐酸阿霉素 (6 .5mg/kg)制成肾病综合征模型。选 8只作为用药组 ,每日灌服黄芪煎剂 ,8只作为对照组 ,每日以 2ml自来水喂饲 ,实验周期 19周。观察指标有 2 4h尿蛋白定量、血白蛋白、血肌酐、尿素氮、胆固醇、甘油三酯、肾对白蛋白排泌率、肾组织病理学变化。结果 :注射盐酸阿霉素 2 0d肾病综合征模型制成。于喂黄芪 1月～4月 ,尿蛋白定量均无减少 ,肾功能无改善 ;喂黄芪后血白蛋白升高 ,于 2月时与治疗组及对照组比较 ,即有显著性差异 ,P <0 .0 5 ;于 3、4月时 ,有非常显著性差异 ,P <0 .0 0 1;于喂黄芪后血胆固醇、甘油三酯均有不同程度降低 ,且肾对白蛋白排泌率也下降 ,于 3月时有统计学意义 ,P <0 .0 5 ;于 4月时有非常显著性差异 ,P <0 .0 0 1。结论 :对肾病综合征大鼠 ,黄芪不减少尿蛋白排泄 ,但使肾脏对白蛋白排泌率降低 ,且可使血白蛋白升高 ,血胆固醇及甘油三酯降低 ,使肾脏的组织病理学损害减轻 ,但对肾功能无明显改善更多还原

【Abstract】 Objective: To determine the therapeutic effect of astragalus membrananus nephrosis syndrome in rats. Methods: Nephrotic syndrome was created in 16 Wistar rats by intravenouse injection of Adriamycin(6.5 mg/kg). Eight rats are used as normal. Eight nephrotic rats were given daily decoction of astragalus membranaceus. Another group of eight rats were given running water(2 ml). 24 hour urine protein excretion rate, serum albumin, plasma creatinine, urea nitrogen, cholesterol, triglyceride, albumin excretion rate and pathological change of renal tissue were observed. Results: Nephrotic syndrome became apparent 20 days after the injection of Adriamycin. After 1～4 months astragalus membranacus treatment, 24h urine protein excretion was not reduced. Renal function did not improved. There was significant increase in plasma albumin at 2 and 4 months(P<0.05). Plasma cholesterol, triglyceride and albumin excretion were significantly reduced by 3(P<0.05) and 4 months(P<0.01). Conclusion: Astragalus membranaceus dose not reduce urine protein excretion but reduces renal albumin excretion rate, plasma chlolesterol or triglyceride and increases plasma albumin. It improves renal pathology but dose not improve renal function.更多还原