【摘要】 目的 :评估银杏叶提取物对慢性高尿酸血症性肾损害的疗效。方法 :113例慢性高尿酸血症伴蛋白尿患者随机分为治疗组 5 8例 ,对照组 5 5例 ,两组同时服用别嘌呤醇 ,每次 0 .1,每日 3次 ,其中治疗组再加服银杏叶提取物 ,每次 80mg ,每日 3次 ,疗程均为 3个月。结果 :疗程结束后 ,治疗组的U -Alb、U -α1-MG、U -Tf、TC、TG、ηb、ηp、FIB均有明显改善 (P <0 .0 0 1) ;与对照组比有显著性差异 (P <0 .0 0 1)。结论 :银杏叶提取物可减少慢性高尿酸血症患者尿微量蛋白的排出 ,降低血粘度和血脂 ,保护肾脏 ,可试用于慢性高尿酸血症早期肾损害的防治。更多还原

【Abstract】 Objective:To evaluate effect of ginkgo biloba extract on renal damage induced by chronic hyperuricemia.Methods:113 Patients of chronic hyperuricemia with proteinuria were randomly divided into ginkgo biloba extract group (58 patients) and contrast group (55 patients).Both groups were given allopurinolum,100mg once,three times a day for 3 months,while ginkgo biloba extract was added with allopurinolum in ginkgo biloba extract group,80mg once,three times a day.Results:After three months,U-Alb?U-α 1-MG?U-Tf?TCH?TG?ηb?ηp?FIB in ginkgo biloba extract group were obviously improved(P<0.001);there was significant difference between two groups(P<0.001).Conclusion:Ginkgo biloba extract can reduce excretion of urine protein in chronic hyperuricemia,decrease blood viscosity and lipid,protect kidney,ginkgo biloba extract can be tried in chronic hyperuricemia to prevent and treat early renal damage.更多还原