【摘要】 目的 :探讨原发性肾病综合征病人尿中丙氨酸氨基肽酶 (AAP)活性变化及其临床意义。方法 :采用改良Jung法分别测定 6 0例原发性肾病综合征病人尿中AAP活性水平 ,根据治疗后尿蛋白水平分为尿蛋白减少组 30例 (2 4小时尿蛋白 <3.5g) ,尿蛋白未减少组 30例 (2 4小时尿蛋白≥ 3.5 g) ,同时观察尿NAG和 β2 -MG在治疗前后的变化。结果 :两组在治疗前尿AAP水平明显升高 ,尿蛋白减少组治疗后尿AAP明显下降 (P <0 0 5 ) ,其下降幅度与尿蛋白减少程度呈正相关 (r =0 .6 7)。与尿NAG和 β2 -MG相比 ,尿AAP反应肾小管的损坏更敏感。结论 :肾病综合征尿AAP活性与尿蛋白水平有关 ,其动态变化能间接反应其肾小管的损坏程度及治疗效果和转归更多还原

【Abstract】 Objective: to investigate the variation and significance of urinary alanine aminopeptidase(AAP) in nephrotic syndrome .Methods: The activity of urinary AAP was studied in 60 patients with nephrotic syndrome(mean age 42±9.8 years, ranging from 17-72 years). According to 24-hours urinary protein after 2 months treatment,these patients were divided into two groups;group 1 included 30 patients with 24-hours urinary protein less than 3.5 g,group 2 included 30 patients with 24-hours urinary protein over 3.5g. The changes of beta2-microglobulin (β 2-MG),N-acety1-beta-D-glucosaminidase(NAG) and AAP were observed before and after therapy.Results: Urinary AAP activity was significantly higher in the two groups before treatment.Levels of 24-hours urinary protein and urinary AAP decreased greatly in the group 1 after therapy than before (P<0 05),and the two parameters was positive relation(r=0.67).In the group 2,urinary AAP was not different after and before treatment.However,urinary AAP indicated more sensitively renal tubular inlury than NAG and β 2-MG.Conclusion: In nephrotic syndrome,urinary AAP activity rises significantly and tsis be associated with the quantity of urinary protein.It could be a helpful early indicator of renal tubular injury.更多还原