【摘要】 以邻氨基苯酚和尿素为原料 ,对环合、硝化、碱性水解的传统工艺进行改进 ,合成了 2 氨基 5 硝基苯酚。研究了影响环合反应的因素 ,优化了反应条件 ,总收率为 80 0 %。最优反应条件为 :n (邻氨基苯酚 )∶n (尿素 ) =1 0 0∶1 0 5 ,于 115℃反应 5 5h ,再硝化、碱性水解得产品。对三步的产品进行了红外光谱分析。传统工艺的收率仅为 36 %～ 5 3% ,三废量大。邻氨基苯酚 -尿素法 ,工艺新颖 ,原料易得、成本低 ,“三废”少。更多还原

【Abstract】 Amino 5 nitrophenol was synthesized using o aminophenol and urea as raw materials through cyclocondensation,nitration and alkaline hydrolysis in turn.Factors influencing the reactions were studied.The overall yield was 80%.The optimum conditions are as follows.In cyclocondensation, o aminophenol and urea (molar ratio 1.00∶1.05) reacted at 115 ℃ for 1.5 h.Nitration was carried out at 40 ℃ for 2 h with HNO\-3 and H\-2SO\-4,and alkaline hydrolysis at 105 ℃ for 2.5 h.The product was characterized by IR.This new method, o aminophenol urea method,is facile,of low cost and lacking in wastes.The overall yield of conventional process is only 36%-53%.更多还原