【摘要】 目的　研究血清白介素 6 (IL 6 )、白介素 8(IL 8)和肿瘤坏死因子 (TNF α)在早期诊断重症急性胰腺炎中的价值。方法　采用双抗体夹心ELISA法检测 41例重症急性胰腺炎(SAP)患者血清IL 6、IL 8和TNF α的水平 ,并与 6 1例轻型急性胰腺炎 (MAP)和 2 0例正常对照组进行比较。结果　入院 2 4h内SAP患者血清IL 6、IL 8和TNF α水平显著高于MAP和正常对照组 (P <0 0 1) ,入院治疗 7d后则下降接近正常水平 ;MAP患者入院时血清TNF α水平显著高于正常对照组 (P <0 0 1) ,IL 6、IL 8则无差异。结论　检测血清IL 6、IL 8和TNF α水平可作为早期诊断重症急性胰腺炎的有效指标之一 ,TNF α在急性胰腺炎从轻型向重症的发展过程中起核心作用更多还原

【Abstract】 Objective To investigate the roles of serum IL 6,IL 8 and TNF α in the early diagnosis of severe acute pancreatitis(SAP).Methods The serum levels of these cytokines in 41 cases of SAP,61 cases of mild acute pancreatitis(MAP) and 20 normal controls were determined by sandwich ELISA method.Results It was found that the serum levels of IL 6,IL 8 and TNF α were markedly higher in SAP than those in MAP and in the normal controls within 24 hours of admission(P<0 01).These decreased close to the normal levels after 7 days treatment.The serum level of TNF α was markedly higher in MAP than that in the normal controls on admission(P<0 01);while the serum levels of IL 6 and IL 8 were slightly but insignificantly higher in MAP compared with the normal controls.Conclusion The determination of serum levels of IL 6,IL 8 and TNF α may be served as effective markers of early SAP.TNF α plays a major role in the course of progression from MAP to SAP. [更多还原